Rubbery Drug-Eluting Electrospun Fiber Mats for Healthcare

This work reports release study of Zafirlukast (ZAF), a model drug from electrospun Allomatrix^TM {(poly(alloocimene-isobutylene-alloocimene) triblock} polymer fiber mat. Allomatrix^TM solution containing 10 wt% ZAF was electrospun onto parchment paper to yield free-standing rubbery fiber mat. ZAF release into phosphate buffered saline (PBS) solution (pH = 7.4) at 37^oC was measured by UV spectroscopy.  70% of the loaded ZAF was released in 21 days from the mat containing ZAF, respectively. Due to the excellent biocompatibility of this block copolymer, with thermoplastic elastomeric properties, this mat holds great promise for drug delivery applications.