Drug Eluting Electrospun Rubbery FIBER Mats

This work reports release studies of acetylsalicylic acid (aspirin), a model drug from electrospun Arbomatrix^TM {a block copolymer with arborescent polyisobutylene (PIB) core and poly (para-methyl styrene) PMS end blocks} and Allomatrix^TM {(poly(alloocimene-isobutylene-alloocimene) triblock}, polymer fiber mats. Arbomatrix^TM solution containing 15 and 30 wt% aspirin and Allomatrix^TM solution containing 10 and 20 wt% aspirin were electrospun onto parchment paper to yield free-standing rubbery fiber mats. Aspirin release into phosphate buffered saline (PBS) solution (pH = 7.4) at 37^oC was measured by UV spectroscopy.  The loaded aspirin was fully released in 72 hours. Due to the excellent biocompatibility of these block copolymers, both with thermoplastic elastomeric properties, these mats hold great promise for drug delivery applications.