Folate Targeted Imaging Agent for Cancer Diagnostic Application through Thermoplastic Elastomeric Fiber Mat

Wednesday, October 12, 2016
Prajakatta Mulay1, Sanghamitra Sen1, Judit E. Puskas1, Andrew McClain2 and Aditya Jindal1, (1)Department of Chemical and Biomolecular Engineering, The University of Akron, Akron, OH, (2)Chemical and Biomolecular, Akron Univeristy, Akron, OH
Polyisobutylene-based thermoplastic elastomers have shown excellent biocompatibility and elastic ability to be spun into fiber mat to encapsulate folate targeted imaging agents. Folate receptors are over-expressed on the surface of human cancer tumor cells and have high affinity towards folate (Vitamin B9). This affinity allows for targeted diagnosing of malignant cells. This project focuses on synthesis of folate molecule that can be attached to a fluorescein derivative to be used as a bio-imaging agent. This agent can be later incorporated into a fiber mat made of poly(alloocimene-b-isobutylene-b-alloocimene) block copolymer thermoplastic elastomer for diagnosis of breast cancer tumor cells.