C-11
Type I and Type IV Circumallergenic Thin Films from Guayule and Hevea Natural Rubber
We have developed Type IV hypoallergenic natural rubber thin films. Latex films were cured with the accelerators diisopropyl xanthogen polysulphide (DIXP) and alkyldithiocarbamate (ZDNC) (Robinson Brothers Ltd., West Bromwich, UK). DIXP is consumed during the vulcanization process, and skin tests have shown that ZDNC does not cause dermal reactions or delayed contact hypersensitivity, thus eliminating Type IV allergy sensitization. In addition, DIXP contains no nitrogen, phosphorous and metallic elements, and so is unable to form the volatile and carcinogenic N-nitrosamine compounds during vulcanization, reducing occupational hazards for latex industry workers.
DIXP and ZDNC were compounded in two different natural rubber lattices that do not elicit a Type I latex allergy sensitization. Circumallergenic natural rubber latex from the plant species Parthenium argentatum, commonly referred to as guayule, was used because its proteins do not cross-react with antibodies raised against Hevea associated allergic proteins. Ultra-low protein natural rubber latex from the plant species Hevea brasiliensis was used to make thin films as well.
Formulations in both lattices generated films which exceeded the ASTM 3577 surgical glove specifications. A multivariate stochastic regression technique was used to demonstrate the individual effect of DIXP, ZDNC, and film thickness on tensile properties of films made from each latex. Comparative analysis of multivariate models provides insight into compounding variations attributed to differences in Guayule vs. Hevea latex composition and chemistry.